Eye movements in mice may predict safety issues with CNS drugs

Assessing changes in the eye movements of mice treated with CNS-active drugs could complement the existing range of in vivo tests to evaluate the efficacy, PK, receptor interactions, and toxicity of a wide range of candidate drug compounds, researchers claim.

Jeremy Nathans, Ph.D., Hugh Cahill, Ph.D., and Amir Rattner, Ph.D., reported in The Journal of Clinical Investigation that treatment with the drugs they tested elicited distinctive and characteristic eye-movement responses that could be analyzed quantitatively to confirm drug dose, duration of action, receptor specificity, blood-brain barrier penetration, and agonist-antagonist interactions.

Link to their paper: JCI – Preclinical assessment of CNS drug action using eye movements in mice.

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